Symbol
Name
ID

Parp1
poly (ADP-ribose) polymerase family, member 1
MGI:1340806

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes

Hyposmia

Spasticity

Bradykinesia

Tremor

Depression

Anxiety

Panic attack

Hallucinations

Apathy

Reduced social reciprocity

Impulsivity

Agitation

Restless legs

Cognitive impairment

Dementia

Frontal lobe dementia

Short attention span

Insomnia

Hyperreflexia

Dyskinesia

Dystonia

Gait imbalance

Postural instability

Abnormal autonomic nervous system physiology

Disease(s) Associated with PARP1

Parkinson's disease

Mouse Phenotypes		decreased neuron apoptosis	decreased susceptibility to dopaminergic neuron neurotoxicity	abnormal microglial cell physiology	increased prepulse inhibition
Availability	Mouse Genotype	decreased neuron apoptosis		abnormal microglial cell physiology	increased prepulse inhibition
	Parp1^{tm1b(EUCOMM)Hmgu}/Parp1^{tm1b(EUCOMM)Hmgu}
	Parp1^tm1Zqw/Parp1^tm1Zqw

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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